Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs.

Journal of postgraduate medicine - 1 Jan 2000

Taur S R, Kulkarni N B, Gandhe P P, Thelma B K, Ravat S H, Gogtay N J, Thatte U M

Abstract excerpt

BACKGROUND AND OBJECTIVE: Epilepsy, the most common neurological disorder, has treatment failure rate of 20 to 25%. Inter-individual variability in drug response can be attributed to genetic polymorphism in genes encoding different drug metabolizing enzymes, drug transporters (P-gp), and enzymes involved in sodium channel biosynthesis. The present study attempted to evaluate association of polymorphisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Carbamazepine

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP2C9

Share to Epilepsy

Share to Pharmacogenetics

Source

Identifiers

PMID: 25121365
DOI: 10.4103/0022-3859.138739

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs.PMID 25121365Read ↗

Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.Semantic proximity Read ↗

Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian populationSemantic proximity Read ↗

Polymorphisms Affecting the Response to Novel Antiepileptic Drugs.Semantic proximity Read ↗

Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy.Semantic proximity Read ↗

A systematic review and meta-analysis of the role of ABCC2 variants on drug response in patients with epilepsy.Semantic proximity Read ↗

Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy.Semantic proximity Read ↗

Genetic factors associated with drug-resistance of epilepsy: relevance of stratification by patient age and aetiology of epilepsy.Semantic proximity Read ↗

Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy.Semantic proximity Read ↗

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.Semantic proximity Read ↗

Genetic Analysis of CYP2C9 with Reference to Drug Response in Epilepsy Patients of Pakistan.Semantic proximity Read ↗

Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study.Semantic proximity Read ↗

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.