Article
Possible role of CYP2C9 & CYP2C19 single nucleotide polymorphisms in drug refractory epilepsy.
The Indian journal of medical research - 1 Sept 2011
Lakhan Ram, Kumari Ritu, Singh Kavita, Kalita Jayanti, Misra Usha Kant, Mittal Balraj
Abstract excerpt
BACKGROUND & OBJECTIVES: Multiple drug resistance in epilepsy is a common problem and one third of epilepsy patients remain non responsive to antiepileptic drug (AED) therapy. In this study we aimed to investigate the relationship between the genetic polymorphism of cytochrome P450 genes, namely CYP2C9 and CYP2C19 with multiple drug resistance in epilepsy patients. METHODS: A total of 402 patients with epilepsy...
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