Article
Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.
Pharmacogenomics - 1 Jul 2010
Grover Sandeep, Gourie-Devi Mandaville, Baghel Ruchi, Sharma Sangeeta, Bala Kiran, Gupta Meena, Narayanasamy Krishnamoorthy, Varma Binuja, Gupta Meenal, Kaur Kavita, Talwar Puneet, Kaur Harpreet, Giddaluru Sudheer, Sharma Abhay, Brahmachari Samir K, Indian Genome Variation Consortium, Kukreti Ritushree
Abstract excerpt
BACKGROUND: The first-line antiepileptic drugs, although affordable and effective in the control of seizures, are associated with adverse drug effects, and there is large interindividual variability in the appropriate dose at which patients respond favorably. This variability may partly be explained by functional consequences of genetic polymorphisms in the drug-metabolizing enzymes, such as the CYP450 family,...
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