Article
Glutathione S-transferase M1 modulates allergen-induced NF-κB activation in asthmatic airway epithelium.
Allergy - 1 Dec 2014
Polosukhin V V, Polosukhin I V, Hoskins A, Han W, Abdolrasulnia R, Blackwell T S, Dworski R
Abstract excerpt
BACKGROUND: Glutathione S-transferase M1 (GSTM1) is a phase II enzyme and regulator of inflammatory signaling in airway epithelial cells. We have found upregulation of neutrophilic airway inflammation in atopic asthmatics expressing GSTM1 gene (GSTM1+) compared to GSTM1null asthmatics. We hypothesized that GSTM1 modulates NF-κB activation in bronchial epithelium in atopic asthmatics. We determined regulation of...
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