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Article

Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Nov 2021

Piaggi Simona, Marchi Elisabetta, Carnicelli Vittoria, Zucchi Riccardo, Griese Matthias, Hector Andreas, Sorio Claudio, Pompella Alfonso, Corti Alessandro

Abstract excerpt

BACKGROUND: Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme that modulates the S-thiolation status of intracellular factors involved in cancer cell survival or in the inflammatory response. Studies focusing on chronic obstructive pulmonary disease (COPD) have demonstrated that GSTO1-1 is detectable in alveolar macrophages, airway epithelium and in the extracellular compartment, where its...

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PMID: 33583732
DOI: 10.1016/j.jcf.2021.01.010

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