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Article

The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects.

The Journal of allergy and clinical immunology - 1 Dec 2009

Alexis Neil E, Zhou Haibo, Lay John C, Harris Bradford, Hernandez Michelle L, Lu Tsui-Shan, Bromberg Philip A, Diaz-Sanchez David, Devlin Robert B, Kleeberger Steven R, Peden David B

Abstract excerpt

BACKGROUND: The glutathione-S-transferase Mu 1 (GSTM1) null genotype has been reported to be a risk factor for acute respiratory disease associated with increases in ambient air ozone levels. Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects. OBJECTIVE: The purpose of...

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Identifiers

PMID: 19796798
DOI: 10.1016/j.jaci.2009.07.036
PMCID: PMC3038610

Genes

GSTM1

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