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Article

Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype.

American journal of respiratory and critical care medicine - 1 Jan 2013

Hoskins Aimee, Reiss Sara, Wu Pingsheng, Chen Ning, Han Wei, Do Rui-hong, Abdolrasulnia Rasul, Dworski Ryszard

Abstract excerpt

RATIONALE: Asthma is a heterogeneous lung disorder characterized by airway inflammation and airway dysfunction, manifesting as hyperresponsiveness and obstruction. Glutathione S-transferase M1 (GSTM1) is a multifunctional phase II enzyme and regulator of stress-activated cellular signaling relevant to asthma pathobiology. A common homozygous deletion polymorphism of the GSTM1 gene eliminates enzyme activity....

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Source

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Identifiers

PMID: 23204253
DOI: 10.1164/rccm.201204-0786OC
PMCID: PMC3570644

Genes

GSTM1

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