Article
The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene.
International archives of allergy and immunology - 1 Jan 2007
Kamada Fumiaki, Mashimo Yoichi, Inoue Hiroki, Shao Chenchen, Hirota Tomomitsu, Doi Satoru, Kameda Makoto, Fujiwara Hiroshi, Fujita Kimie, Enomoto Tadao, Sasaki Sei, Endo Hiroko, Takayanagi Reiko, Nakazawa Chifuyu, Morikawa Toshio, Morikawa Miki, Miyabayashi Shigeaki, Chiba Yasushi, Tamura Gen, Shirakawa Taro, Matsubara Yoichi, Hata Akira, Tamari Mayumi, Suzuki Yoichi
Abstract excerpt
BACKGROUND: Bronchial asthma is a chronic airway disorder characterized by bronchial inflammation. Oxidative stress is a key component of inflammation. Glutathione S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferases (GSTs) in lung epithelium, plays a key role in cellular protection against oxidative stress. Several studies have shown that the GSTP1 geneis involved in the pathogenesis of...
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