Article
BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay.
Diagnostic pathology - 19 Apr 2016
Tatsuno Michiko, Shioda Yoko, Iwafuchi Hideto, Yamazaki Shigeki, Iijima Kenta, Takahashi Chiaki, Ono Hiromi, Uchida Kiyono, Okamura Osamu, Matubayashi Mamoru, Okuyama Torayuki, Matsumoto Kimikazu, Yoshioka Takako, Nakazawa Atsuko
Abstract excerpt
BACKGROUND: BRAF (V-raf murine sarcoma viral oncogene homolog B1) is a serine-threonine protein kinase involved in cell survival, proliferation, and differentiation. The most common missense mutation of BRAF (mainly V600E) contributes to the incidence of various cancers, including Langerhans cell histiocytosis (LCH). BRAF inhibitors molecularly targeting the V600E mutation have been developed to counteract the...
Topics
- Adolescent
- Antigens, CD1
- Base Sequence
- Case-Control Studies
- Cell Line
- Child
- Child, Preschool
- DNA Mutational Analysis
- Female
- Fixatives