Article
BRAF V600E Mutation in Cell-Free DNA, Rather than in Lesion Tissues, at Diagnosis Is An Independent Prognostic Factor in Children with Langerhans Cell Histiocytosis.
Molecular cancer therapeutics - 1 Jul 2021
Wang Chan-Juan, Cui Lei, Ma Hong-Hao, Wang Dong, Zhang Li, Lian Hong-Yun, Li Wei-Jing, Zhang Qing, Wang Tian-You, Li Zhi-Gang, Zhang Rui
Abstract excerpt
The aim of this study was to investigate the prognostic significance of BRAFV600E in cell-free (cf) DNA (cfBRAFV600E) and lesion tissues (ltBRAFV600E) in pediatric Langerhans cell histiocytosis (LCH). This study included a total of 140 patients with successfully detected cfBRAFV600E and ltBRAFV600E at diagnosis. Treatment response at week 6 was correlated with both cfBRAFV600E and ltBRAFV600E Moreover, the...
Topics
- Adolescent
- Age Factors
- Alleles
- Amino Acid Substitution
- Antineoplastic Combined Chemotherapy Protocols
- Biomarkers, Tumor
- Child
- Child, Preschool
- Circulating Tumor DNA
- Female