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Article

The deubiquitinating enzyme USP24 is a regulator of the UV damage response.

Cell reports - 13 Jan 2015

Zhang Ling, Nemzow Leah, Chen Hua, Lubin Abigail, Rong Xi, Sun Zhongyi, Harris Thomas K, Gong Feng

Abstract excerpt

Regulation of p53 by ubiquitination and deubiquitination is important for its function. In this study, we demonstrate that USP24 deubiquitinates p53 in human cells. Functional USP24 is required for p53 stabilization, and p53 destabilization in USP24-depleted cells can be corrected by the forced expression of USP24. We show that USP24 depletion renders cells resistant to apoptosis after UV irradiation, consistent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 25578727
DOI: 10.1016/j.celrep.2014.12.024
PMCID: PMC4359050

Genes

USP24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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