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Article

XPC promotes MDM2-mediated degradation of the p53 tumor suppressor.

Molecular biology of the cell - 1 Jan 2014

Krzeszinski Jing Yan, Choe Vitnary, Shao Jia, Bao Xin, Cheng Haili, Luo Shiwen, Huo Keke, Rao Hai

Abstract excerpt

Although ubiquitin receptor Rad23 has been implicated in bringing ubiquitylated p53 to the proteasome, how Rad23 recognizes p53 remains unclear. We demonstrate that XPC, a Rad23-binding protein, regulates p53 turnover. p53 protein in XPC-deficient cells remains ubiquitylated, but its association...

Read the complete abstract on PubMed

Topics

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Share to DNA-Binding Proteins
Share to DNA Repair Enzymes
Share to Proteasome Endopeptidase Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Binding

Share to Proteolysis

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

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Source

Open in PubMed Open full text

Identifiers

PMID: 24258024
DOI: 10.1091/mbc.E13-05-0293
PMCID: PMC3890342

Genes

XPC
MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24258024-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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XPC promotes MDM2-mediated degradation of the p53 tumor suppressor.PMID 24258024Read ↗

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