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Article

Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.

The FEBS journal - 1 Mar 2018

Higa Mitsuru, Tanaka Kiyoji, Saijo Masafumi

Abstract excerpt

Transcription-coupled nucleotide excision repair (TC-NER) is a subpathway of nucleotide excision repair that efficiently removes transcription-blocking DNA damage from the transcribed strands of active genes. UVSSA is a causative gene for UV-sensitive syndrome (UVS S), which is an autosomal recessive disorder characterized by hypersensitivity to UV light and deficiency in TC-NER. UV-stimulated scaffold protein A...

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Source

Identifiers

PMID: 29323787
DOI: 10.1111/febs.14382

Genes

UVSSA
USP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.PMID 29323787Read ↗

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.Semantic proximity Read ↗

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Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.Semantic proximity Read ↗

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Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.Semantic proximity Read ↗

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage responseSemantic proximity Read ↗

The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.Semantic proximity Read ↗

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