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Article

Flexibility and mutagenic resiliency of glycosyltransferases.

Glycoconjugate journal - 1 Oct 2014

Bay Marie Lund, Cuesta-Seijo Jose A, Weadge Joel T, Persson Mattias, Palcic Monica M

Abstract excerpt

The human blood group A and B antigens are synthesized by two highly homologous enzymes, glycosyltransferase A (GTA) and glycosyltransferase B (GTB), respectively. These enzymes catalyze the transfer of either GalNAc or Gal from their corresponding UDP-donors to αFuc1-2βGal-R terminating acceptors. GTA and GTB differ at only four of 354 amino acids (R176G, G235S, L266M, G268A), which alter the donor specificity...

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Identifiers

PMID: 25117515
DOI: 10.1007/s10719-014-9542-x

Genes

ABO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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