Article
Turning universal O into rare Bombay type blood.
Nature communications - 30 Mar 2023
Anso Itxaso, Naegeli Andreas, Cifuente Javier O, Orrantia Ane, Andersson Erica, Zenarruzabeitia Olatz, Moraleda-Montoya Alicia, García-Alija Mikel, Corzana Francisco, Del Orbe Rafael A, Borrego Francisco, Trastoy Beatriz, Sjögren Jonathan, Guerin Marcelo E
Abstract excerpt
Red blood cell antigens play critical roles in blood transfusion since donor incompatibilities can be lethal. Recipients with the rare total deficiency in H antigen, the Oh Bombay phenotype, can only be transfused with group Oh blood to avoid serious transfusion reactions. We discover FucOB from the mucin-degrading bacteria Akkermansia muciniphila as an α-1,2-fucosidase able to hydrolyze Type I, Type II, Type III...
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