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Article

Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase.

Transfusion - 1 May 2007

Hosseini-Maaf Bahram, Letts James A, Persson Mattias, Smart Elizabeth, LePennec Pierre-Yves, Hustinx Hein, Zhao Zhihon, Palcic Monica M, Evans Stephen V, Chester M Alan, Olsson Martin L

Abstract excerpt

BACKGROUND: Four amino-acid-changing polymorphisms differentiate the blood group A and B alleles. Multiple missense mutations are associated with weak expression of A and B antigens but the structural changes causing subgroups have not been studied. STUDY DESIGN AND METHODS: Individuals or families having serologically weak B antigen on their red cells were studied. Alleles were characterized by sequencing of...

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Share to ABO Blood-Group System
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosyltransferases

Share to Mutation, Missense

Share to Protein Structure, Secondary

Share to Protein Structure, Tertiary

Share to Structure-Activity Relationship

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Source

Identifiers

PMID: 17465952
DOI: 10.1111/j.1537-2995.2007.01203.x

Genes

ABO

Provenance

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