Population-Specific H-Antigen Chain-Type Variation and Its Potential Impact on Enzymatic Universal-Blood Conversion: A Computational Pilot Study

Abstract excerpt

Enzymatic conversion of donor blood to universal type O ("ECO blood") is an active area of transfusion medicine research, with recently discovered bacterial enzymes capable of removing canonical and structurally extended ABO blood-group antigens. Whether human genetic variation affecting antigen chaintype distribution influences the efficiency of these conversion enzymes has not previously been examined. Using Fuc...

Topics

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• Blood groups and transfusion
• Blood transfusion and management
• Glycosylation and Glycoproteins Research

Identifiers and source

Literature Corpus work

aff0b1fc-bfb5-5fd3-af5a-a28ce5c9b16f

DOI

10.26434/chemrxiv.15007953/v1