Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of amino acid substitution p.Asp183Gly of A-glycosyltransferase enzyme in an individual with the AweakB phenotype.

Transfusion - 1 Jan 2026

He Yunlei, Yu Lu, Zhang Jiwei, Niu Di, Liu Yiyu, Zhong Fade

Abstract excerpt

BACKGROUND: Amino acid substitutions resulting from variants in the ABO gene are often found to impact glycosyltransferase function, leading to incomplete glycosylation of the H antigen and the emergence of ABO subgroups with weak A or B phenotypes. Here, we identify a novel ABO*AW allele and investigate the underlying mechanism. STUDY DESIGN AND METHODS: RBCs were phenotyped by standard serology methods. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ABO Blood-Group System
Share to Alleles
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ABO gene

Share to Glycosyltransferases

Share to Mutation, Missense

Share to Phenotype

Source

Identifiers

PMID: 41268803
DOI: 10.1111/trf.18487

Genes

ABO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of amino acid substitution p.Asp183Gly of A-glycosyltransferase enzyme in an individual with the AweakB phenotype.PMID 41268803Read ↗

Identification of a novel variant c.761C>T on ABO*B.01 gene in ABO glycosyltransferases associated with Bweak phenotype.Semantic proximity Read ↗

One novel single nucleotide polymorphism c.424A>G on A1.02 allele in ABO glycosyltransferases leads to Aweak phenotype.Semantic proximity Read ↗

Mechanism evaluation for an amino acid substitution p.Y246C of B-glycosyltransferase enzyme with Bweak phenotype.Semantic proximity Read ↗

The p.R168Q mutation is associated with the Bw phenotype and a predicted decrease in the stability of the resulting ABO glycosyltransferase.Semantic proximity Read ↗

Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase.Semantic proximity Read ↗

An age-dependent ABO discrepancy between mother and baby reveals a novel A(weak) allele.Semantic proximity Read ↗

Two novel mutations p. L319V and p. L91P in ABO glycosyltransferases lead to Ael and Bel phenotypes.Semantic proximity Read ↗

[Identification of a glycosyltransferase allele associated with Bw subtype and analysis of the protein structure].Semantic proximity Read ↗

Serological and molecular characterization of novel ABO variants including an interesting B(A) subgroup.Semantic proximity Read ↗

Molecular genetics and genomics of the ABO blood group systemSemantic proximity Read ↗

Six splice site variations, three of them novel, in the ABO gene occurring in nine individuals with ABO subtypes.Semantic proximity Read ↗

[Study of the molecular characteristics of a Bweak phenotype due to a novel c.398T>C variant of the ABO gene].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.