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Article

Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

The Journal of biological chemistry - 5 Nov 1990

Yamamoto F, Hakomori S

Abstract excerpt

Four amino acid substitutions (aa 176, 235, 266, and 268) have been found between the coding regions of cDNAs for histo-blood group A and B transferases (Yamamoto F., Clausen, H., White, T., Marken, J., and Hakomori, S. (1990) Nature 345, 229-233). Here we establish the basis of differential affinity of these glycosyltransferases to nucleotide-sugar (UDP-GalNAc or UDP-Gal). On the basis of gene reconstruction...

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PMID: 2121736

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