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Article

A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase.

The Journal of biological chemistry - 4 Apr 2003

Marcus Sandra L, Polakowski Robert, Seto Nina O L, Leinala Eeva, Borisova Svetlana, Blancher Antoine, Roubinet Francis, Evans Stephen V, Palcic Monica M

Abstract excerpt

Blood group A and B antigens are carbohydrate structures that are synthesized by glycosyltransferase enzymes. The final step in B antigen synthesis is carried out by an alpha1-3 galactosyltransferase (GTB) that transfers galactose from UDP-Gal to type 1 or type 2, alphaFuc1-->2betaGal-R (H)-terminating acceptors. Similarly the A antigen is produced by an alpha1-3 N-acetylgalactosaminyltransferase that transfers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12529355
DOI: 10.1074/jbc.M212002200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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