Article
The importance of disordered loops in ABO glycosyltransferases.
Transfusion medicine reviews - 1 Jul 2005
Yazer Mark H, Palcic Monica M
Abstract excerpt
The human ABO antigens are carbohydrates that differ from each other by the immunodominant sugar. The O phenotype is characterized by the absence of the A- or B-defining carbohydrate. The glycosyltransferases that create the A and B antigens share a considerable amino acid sequence and a structural homology and feature 2 series of amino acids whose exact location within the enzymes' structure cannot be...
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