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Article

Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Serpente Maria, Fenoglio Chiara, Clerici Francesca, Bonsi Rossana, Arosio Beatrice, Cioffi Sara M G, Rotondo Emanuela, Franceschi Massimo, Martinelli Boneschi Filippo, Mari Daniela, Mariani Claudio, Scarpini Elio, Galimberti Daniela

Abstract excerpt

We carried out an association study of transmembrane protein 106B gene (TMEM106B) rs1020004 A/G, rs6966915C/T, and rs1990622 A/G in a population of 656 patients with Alzheimer's disease (AD) and 619 controls, and tested whether the rs1990622 influences plasma progranulin levels. No differences in allele and genotype distribution were observed between cases and controls, even stratifying according to APOE status...

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Share to Aged, 80 and over
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Source

Identifiers

PMID: 25114081
DOI: 10.3233/JAD-141167

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transmembrane protein 106B gene (TMEM106B) variability and influence on progranulin plasma levels in patients with Alzheimer's disease.PMID 25114081Read ↗

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TMEM106B expression is reduced in Alzheimer’s disease brainsSemantic proximity Read ↗

rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.Semantic proximity Read ↗

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TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

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