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Article

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.

Archives of neurology - 1 May 2011

Cruchaga Carlos, Graff Caroline, Chiang Huei-Hsin, Wang Jun, Hinrichs Anthony L, Spiegel Noah, Bertelsen Sarah, Mayo Kevin, Norton Joanne B, Morris John C, Goate Alison

Abstract excerpt

OBJECTIVE: To test whether rs1990622 (TMEM106B) is associated with age at onset (AAO) in granulin (GRN) mutation carriers and with plasma GRN levels in mutation carriers and healthy, elderly individuals. Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneration wi...

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Identifiers

PMID: 21220649
DOI: 10.1001/archneurol.2010.350
PMCID: PMC3090529

Genes

GRN
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21220649-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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