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Article

Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers.

Molecular psychiatry - 1 Oct 2026

Pagano Lorenzo, Saraceno Claudia, Geviti Andrea, Fostinelli Silvia, Facconi Alessandro, Laganà Valentina, Giacomucci Giulia, Cotelli Maria Sofia, Ingannato Assunta, Bagnoli Silvia, Longobardi Antonio, Russotto Alice, Bellini Sonia, Lagrotteria Davide, Paparazzo Ersilia, Binetti Giuliano, Montesanto Alberto, Nacmias Benedetta, Maletta Raffaele, Borroni Barbara, Ghidoni Roberta

Abstract excerpt

One of the major causative genes involved in Frontotemporal dementia (FTD) is Granulin (GRN), encoding for Progranulin (PGRN). GRN mutation carriers show a substantial heterogeneity with high variability in age at onset and pathological presentation, even within the same family or identical mutations, suggesting the presence of additional genetic factors. Single nucleotide polymorphisms in the Transmembrane...

Read the complete abstract on PubMed

Topics

Humans
Progranulins
Age of Onset
Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Intercellular Signaling Peptides and Proteins

Polymorphism, Single Nucleotide

Frontotemporal Dementia

Mutation

Nerve Tissue Proteins

Female

Genetic Predisposition to Disease

Male

Middle Aged

Heterozygote

Aged

Linkage Disequilibrium

Genotype

Italy

Source

Open in PubMed Open full text

Identifiers

PMID: 42151443
DOI: 10.1038/s41380-026-03653-w
PMCID: PMC13569440

Genes

GRN
TMEM106B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers.PMID 42151443Read ↗

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.Semantic proximity Read ↗

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Semantic proximity Read ↗

Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementiaSemantic proximity Read ↗

Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions.Semantic proximity Read ↗

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.Semantic proximity Read ↗

Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.Semantic proximity Read ↗

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Clinical variability and onset age modifiers in an extended Belgian GRN founder familySemantic proximity Read ↗

Frontotemporal Dementia due to the Novel GRN Arg161GlyfsX36 Mutation.Semantic proximity Read ↗

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