Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Genetic Alterations of<i>AXIN2</i>Gene in Adrenocortical Tumors

7 Jul 2011

Abstract excerpt

BACKGROUND: Mutations of the β-catenin gene (CTNNB1), which lead to constitutive activation of Wnt signaling, have recently been described in adrenocortical adenomas (AA) and carcinomas (ACC). However, somatic CTNNB1 mutations may explain only about 50% of β-catenin accumulation observed in adrenocortical tumors, indicating that other components of the Wnt pathway may be involved. OBJECTIVE: The objective of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal and Paraganglionic Tumors
Share to Cardiac tumors and thrombi
Share to Pituitary Gland Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21733995
DOI: 10.1210/jc.2010-2987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Genetic Alterations of<i>AXIN2</i>Gene in Adrenocortical TumorsPMID 21733995Read ↗

Molecular Markers and the Pathogenesis of Adrenocortical CancerSemantic proximity Read ↗

Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas.Semantic proximity Read ↗

Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.Semantic proximity Read ↗

Genetics of Adrenocortical Development and Tumors.Semantic proximity Read ↗

Activating mutations in CTNNB1 in aldosterone producing adenomas.Semantic proximity Read ↗

CTNNB1Mutation in Aldosterone Producing AdenomaSemantic proximity Read ↗

[Pathogenesis of adrenocortical cancer].Semantic proximity Read ↗

Comprehensive analysis of CTNNB1 in adrenocortical carcinomas: Identification of novel mutations and correlation to survivalSemantic proximity Read ↗

The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.Semantic proximity Read ↗

Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.Semantic proximity Read ↗

Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.Semantic proximity Read ↗

Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.