Article
Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas.
European journal of endocrinology - 1 Mar 2014
Ragazzon Bruno, Libé Rossella, Assié Guillaume, Tissier Frédérique, Barreau Olivia, Houdayer Claude, Perlemoine Karine, Audebourg Anne, Clauser Eric, René-Corail Fernande, Bertagna Xavier, Dousset Bertrand, Bertherat Jérôme, Groussin Lionel
Abstract excerpt
CONTEXT: Adrenocortical carcinoma (ACC) is a rare disease with a poor overall outcome. Transcriptome analysis identified two groups of ACCs with different prognosis. In aggressive ACCs, somatic mutations of the tumor suppressor gene TP53 and the proto-oncogene β-catenin are detected in 50% of cases. For the remaining aggressive ACCs and for the group with a better prognosis, molecular alterations are unknown....
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