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Integrated Analysis of Genome-Wide Methylation and Gene Expression Shows Epigenetic Regulation of <i>CYP11B2</i> in Aldosteronomas

12 Dec 2013

Abstract excerpt

CONTEXT: Differential methylation of CpG regions is the best-defined mechanism of epigenetic regulation of gene expression. OBJECTIVE: Our objective was to determine whether any changes in methylation are associated with aldosteronomas. METHODS: We performed integrated genome-wide methylation and gene expression profiling in aldosteronomas (n = 25) as compared with normal adrenal cortical tissue (n = 10) and...

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PMID: 24423307
DOI: 10.1210/jc.2013-3495

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