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A Novel Patient-Derived Cell Line of Adrenocortical Carcinoma Shows a Pathogenic Role of Germline MUTYH Mutation and High Tumour Mutational Burden

2020-12-15

Abstract excerpt

<title>Abstract</title> <p>BackgroundThe response of advanced adrenocortical carcinoma (ACC) to current chemotherapies is unsatisfactory and a limited rate of response to immunotherapy was observed in clinical trials. High tumour mutational burden (TMB) and the presence of a specific DNA signature are characteristic features of tumours with mutations in the gene <italic>MUTYH</italic> encoding the mutY DNA glycos...

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Literature Corpus work
e63ca040-f3dd-534e-8284-a2a200fd54a6
DOI
10.21203/rs.3.rs-125950/v1
Open publication

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A Novel Patient-Derived Cell Line of Adrenocortical Carcinoma Shows a Pathogenic Role of Germline MUTYH&nbsp;Mutation and High Tumour Mutational BurdenDOI 10.21203/rs.3.rs-125950/v1
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