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Article

A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence.

British journal of cancer - 1 Apr 2020

Surakhy Mirvat, Wallace Marsha, Bond Elisabeth, Grochola Lukasz Filip, Perez Husein, Di Giovannantonio Matteo, Zhang Ping, Malkin David, Carter Hannah, Parise Ivy Zortea S, Zambetti Gerard, Komechen Heloisa, Paraizo Mariana M, Pagadala Meghana S, Pinto Emilia M, Lalli Enzo, Figueiredo Bonald C, Bond Gareth L

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in Southern Brazil due to the TP53 p.R337H (R337H) germline mutation. The heterogeneous risk...

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Identifiers

PMID: 32147670
DOI: 10.1038/s41416-020-0764-3
PMCID: PMC7156685

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