Article
Genotyping single nucleotide polymorphisms using different molecular beacon multiplexed within a suspended core optical fiber.
Sensors (Basel, Switzerland) - 8 Aug 2014
Nguyen Linh Viet, Giannetti Sara, Warren-Smith Stephen, Cooper Alan, Selleri Stefano, Cucinotta Annamaria, Monro Tanya
Abstract excerpt
We report a novel approach to genotyping single nucleotide polymorphisms (SNPs) using molecular beacons in conjunction with a suspended core optical fiber (SCF). Target DNA sequences corresponding to the wild- or mutant-type have been accurately recognized by immobilizing two different molecular beacons on the core of a SCF. The two molecular beacons differ by one base in the loop-probe and utilize different...
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