Article
Mutational landscape of candidate genes in familial prostate cancer.
The Prostate - 1 Oct 2014
Johnson Anna M, Zuhlke Kimberly A, Plotts Chris, McDonnell Shannon K, Middha Sumit, Riska Shaun M, Schaid Daniel J, Thibodeau Stephen N, Douglas Julie A, Cooney Kathleen A
Abstract excerpt
BACKGROUND: Family history is a major risk factor for prostate cancer (PCa), suggesting a genetic component to the disease. However, traditional linkage and association studies have failed to fully elucidate the underlying genetic basis of familial PCa. METHODS: Here, we use a candidate gene approach to identify potential PCa susceptibility variants in whole exome sequencing data from familial PCa cases. Six...
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