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Article

Smooth muscle cell phenotypic switch: implications for foam cell formation.

Current opinion in lipidology - 1 Oct 2014

Chaabane Chiraz, Coen Matteo, Bochaton-Piallat Marie-Luce

Abstract excerpt

PURPOSE OF REVIEW: It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant number of foam cells as well. During atherosclerotic plaque formation, SMCs switch from a...

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Share to Atherosclerosis
Share to Endothelium, Vascular
Share to Foam Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

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Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

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Source

Identifiers

PMID: 25110900
DOI: 10.1097/MOL.0000000000000113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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