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Article

Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis.

Journal of the American Heart Association - 17 Oct 2023

Chen Runji, McVey David G, Shen Daifei, Huang Xiaoxin, Ye Shu

Abstract excerpt

The medial layer of the arterial wall is composed mainly of vascular smooth muscle cells (VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their primary function is to regulate vascular tone. In contrast with terminally differentiated cells, VSMCs possess phenotypic plasticity, capable of transitioning into other cellular phenotypes in response to changes in the vascular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37815057
DOI: 10.1161/JAHA.123.031121
PMCID: PMC10757534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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