Article
RNAi screen for rapid therapeutic target identification in leukemia patients.
Proceedings of the National Academy of Sciences of the United States of America - 26 May 2009
Tyner Jeffrey W, Deininger Michael W, Loriaux Marc M, Chang Bill H, Gotlib Jason R, Willis Stephanie G, Erickson Heidi, Kovacsovics Tibor, O'Hare Thomas, Heinrich Michael C, Druker Brian J
Abstract excerpt
Targeted therapy has vastly improved outcomes in certain types of cancer. Extension of this paradigm across a broad spectrum of malignancies will require an efficient method to determine the molecular vulnerabilities of cancerous cells. Improvements in sequencing technology will soon enable high-throughput sequencing of entire genomes of cancer patients; however, determining the relevance of identified sequence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.