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Article

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells.

Blood - 1 May 2014

Cook Amy M, Li Liang, Ho Yinwei, Lin Allen, Li Ling, Stein Anthony, Forman Stephen, Perrotti Danilo, Jove Richard, Bhatia Ravi

Abstract excerpt

Acute myeloid leukemia (AML) is sustained by small populations of leukemia stem cells (LSCs) that can resist available treatments and represent important barriers to cure. Although previous studies have shown increased signal transducer and activator of transcription (STAT)3 and STAT5 phosphorylation in AML leukemic blasts, the role of Janus kinase (JAK) signaling in primary AML compared with normal stem cells...

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Topics

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Share to Antigens, CD34
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinases

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Share to Receptors, Growth Factor

Share to STAT Transcription Factors

Share to STAT3 Transcription Factor

Share to STAT5 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 24668492
DOI: 10.1182/blood-2013-05-505735
PMCID: PMC4007609

Genes

FLT3
JAK2
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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