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Article

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

20 Nov 2007

Abstract excerpt

Despite vast improvements in our understanding of cancer genetics, a large percentage of cancer cases present without knowledge of the causative genetic events. Tyrosine kinases are frequently implicated in the pathogenesis of numerous types of cancer, but identification and validation of tyrosine kinase targets in cancer can be a time-consuming process. We report the establishment of an efficient, functional...

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Share to Acute Myeloid Leukemia Research
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PMID: 18025156
DOI: 10.1182/blood-2007-06-097253

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