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Article

Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival.

Breast cancer research and treatment - 1 Apr 2010

Cleveland Rebecca J, Gammon Marilie D, Long Chang-Min, Gaudet Mia M, Eng Sybil M, Teitelbaum Susan L, Neugut Alfred I, Santella Regina M

Abstract excerpt

Obesity is a strong risk factor for breast cancer in postmenopausal women and adverse prognostic indicator regardless of menopausal status. Leptin is an important regulator of adipose tissue mass and has been associated with tumor cell growth. Leptin exerts its effects through interaction with the leptin receptor (LEPR). We investigated whether genetic variations in the leptin (LEP) and LEPR genes are associated...

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Source

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Identifiers

PMID: 19697123
DOI: 10.1007/s10549-009-0503-1
PMCID: PMC3571680

Genes

LEP
LEPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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