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Article

The dynamics of interconverting D- and E-forms of the HIV-1 integrase N-terminal domain.

European biophysics journal : EBJ - 1 Nov 2014

Sangeetha Balasubramanian, Muthukumaran Rajagopalan, Amutha Ramaswamy

Abstract excerpt

The N-terminal domain (NTD) of HIV-1 integrase adopts two inter-converting forms (D- and E-) due to their specific coordination of a Zn(2+) ion by an HHCC motif. Mutational studies on NTD have suggested the importance of conformational transition in regulating the functions of tetramers and dimers of HIV-1 integrase. This study explores the stability and dynamics of native NTD forms and the conformational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25106127
DOI: 10.1007/s00249-014-0979-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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