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Computational Elucidation of Possible Contributors to Formation and Stabilization of ATP-Lid Down-Conformation in the N-Terminal Domain of Hsp90.

Proteins - 1 Oct 2025

Gohda Keigo

Abstract excerpt

Heat shock protein 90 (Hsp90) controls activation and maturation of various crucial client proteins through a catalytic cycle. In this catalytic cycle, closure of the lid segment from up- to down-conformation in the N-terminal domain (NTD) of Hsp90 through ATP binding is indispensable for coordinated structural changes, including interchange of dimeric Hsp90 structure between open and closed forms. However, the...

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PMID: 40464224
DOI: 10.1002/prot.26849

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