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Article

Large-scale conformational dynamics of the HIV-1 integrase core domain and its catalytic loop mutants.

Biophysical journal - 1 May 2005

Lee Matthew C, Deng Jinxia, Briggs James M, Duan Yong

Abstract excerpt

HIV-1 integrase is one of the three essential enzymes required for viral replication and has great potential as a novel target for anti-HIV drugs. Although tremendous efforts have been devoted to understanding this protein, the conformation of the catalytic core domain around the active site, particularly the catalytic loop overhanging the active site, is still not well characterized by experimental methods due...

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Identifiers

PMID: 15731379
DOI: 10.1529/biophysj.104.058446
PMCID: PMC1305464

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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