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Mechanism of Mutation-Induced Effects on the Catalytic Function of TEV Protease: A Molecular Dynamics Study.

Molecules (Basel, Switzerland) - 29 Feb 2024

Wang Jingyao, Xu Yicong, Wang Xujian, Li Jiahuang, Hua Zichun

Abstract excerpt

Tobacco etch virus protease (TEVp) is wildly exploited for various biotechnological applications. These applications take advantage of TEVp's ability to cleave specific substrate sequences to study protein function and interactions. A major limitation of this enzyme is its relatively slow catalytic rate. In this study, MD simulations were conducted on TEV enzymes and known highly active mutants (eTEV and uTEV3)...

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PMID: 38474583
DOI: 10.3390/molecules29051071
PMCID: PMC10934673

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