Article
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.
Obesity (Silver Spring, Md.) - 1 Dec 2007
Fiorito Mirella, Torrente Isabella, De Cosmo Salvatore, Guida Valentina, Colosimo Alessia, Prudente Sabrina, Flex Elisabetta, Menghini Rossella, Miccoli Roberto, Penno Giuseppe, Pellegrini Fabio, Tassi Vittorio, Federici Massimo, Trischitta Vincenzo, Dallapiccola Bruno
Abstract excerpt
Type 2 iodothyronine deiodinase (DIO2) converts thyroid prohormone tetraiodothyronine into the biologically active triiodothyronine hormone, which increases insulin sensitivity at the skeletal muscle level. The DIO2 T92A polymorphism modulates deiodinase activity and has been inconsistently associated with insulin resistance. Also, the P121A polymorphism of the peroxisome proliferator-activated receptor (PPAR)...
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