Article
Cytology specimens offer an effective alternative to formalin-fixed tissue as demonstrated by novel automated detection for ALK break-apart FISH testing and immunohistochemistry in lung adenocarcinoma.
Cancer cytopathology - 1 Nov 2014
Rosenblum Frida, Hutchinson Lloyd M, Garver Joann, Woda Bruce, Cosar Ediz, Kurian Elizabeth M
Abstract excerpt
BACKGROUND: Minimally invasive sampling by cytology or core needle biopsy often provides an initial diagnosis for treatment in patients with lung nodules. From these limited specimens, multiple molecular studies are frequently requested. Current guidelines from the US Food and Drug Administration recommend using formalin-fixed paraffin-embedded tissue sections for the detection of anaplastic lymphoma kinase (ALK)...
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