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A fluorescence in situ hybridization-based assay for improved detection of lung cancer cells in bronchial washing specimens

9 Jul 2002

Abstract excerpt

BACKGROUND: Interphase fluorescence in situ hybridization (FISH) is a powerful tool for detecting chromosome and locus-specific changes in tumor cells. We developed a FISH-based assay to detect genetic changes in bronchial washing specimens of lung carcinoma patients. METHODS: The assay uses a mixture of fluorescently labeled probes to the centromeric region of chromosome 1 and to the 5p15, 8q24 (site of the...

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PMID: 12378599
DOI: 10.1002/cncr.10720

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