Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.

The American journal of pathology - 1 Apr 2010

Asano Yoshihide, Stawski Lukasz, Hant Faye, Highland Kristin, Silver Richard, Szalai Gabor, Watson Dennis K, Trojanowska Maria

Abstract excerpt

Systemic sclerosis or scleroderma (SSc) is a complex autoimmune connective tissue disease characterized by obliterative vasculopathy and tissue fibrosis. The molecular mechanisms underlying SSc vasculopathy are largely unknown. Friend leukemia integration factor 1 (Fli1), an important regulator of immune function and collagen fibrillogenesis, is expressed at reduced levels in endothelial cells in affected skin of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microcirculation

Share to Permeability

Share to Proto-Oncogene Protein c-fli-1

Share to Scleroderma, Systemic

Share to Vascular Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 20228226
DOI: 10.2353/ajpath.2010.090593
PMCID: PMC2843486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.PMID 20228226Read ↗

The impact of transcription factor Fli1 deficiency on the regulation of angiogenesisSemantic proximity Read ↗

Epigenetic suppression of Fli1, a potential predisposing factor in the pathogenesis of systemic sclerosis.Semantic proximity Read ↗

A possible contribution of endothelial <scp>CCN</scp>1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosisSemantic proximity Read ↗

Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis.Semantic proximity Read ↗

Recent advances in animal models of systemic sclerosisSemantic proximity Read ↗

Endothelial CCR6 Expression Due to FLI1 Deficiency Contributes to Vasculopathy Associated with Systemic SclerosisSemantic proximity Read ↗

Fli1 and Tissue Fibrosis in Various DiseasesSemantic proximity Read ↗

[A Uuifying hypothesis for the pathogenesis of systemic sclerosis based on the deficiency of transcription factor Fli1 - the development of a new animal model of systemic sclerosis -].Semantic proximity Read ↗

Endothelial Cells Recruit Macrophages and Contribute to a Fibrotic Milieu in Bleomycin Lung InjurySemantic proximity Read ↗

Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis.Semantic proximity Read ↗

Mechanisms of vascular damage in systemic sclerosis.Semantic proximity Read ↗

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.