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SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner

5 Aug 2014

Abstract excerpt

BACKGROUND: Cancer stemness, observed in several types of glioma stem cells (GSCs), has been demonstrated to be an important barrier for efficient cancer therapy. We have previously reported that cancerous neural stem cells (F3.Ras.CNSCs), derived from immortalized human neural stem cells by a single oncogenic stimulation, form glial tumors in vivo. METHOD: We searched for a commonly expressed stress modulator in...

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PMID: 25096191
DOI: 10.1093/neuonc/nou145

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