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Article

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance

2 May 2019

Abstract excerpt

Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable to initiate new tumors contributing to Glioma progression, maintenance, hierarchy and complexity. GSCs are highly resistant to chemo and radiotherapy. These cells are believed to be responsible for tumor relapses and patients’ fatal outcome after developing a recurrent Glioblastoma (GBM) or High Grade...

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PMID: 31119097
DOI: 10.3389/fonc.2019.00292

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