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Article

SIRT1‐mediated transcriptional regulation of SOX2 is important for self‐renewal of liver cancer stem cells

17 Jun 2016

Abstract excerpt

UNLABELLED: Hepatocellular carcinoma (HCC) is a highly aggressive liver tumor containing cancer stem cells (CSCs), which participate in tumor invasion, therapeutic resistance, and tumor relapse leading to poor outcome and limited therapeutic options. Histone deacetylatase sirtuin 1 (SIRT1) has been shown to be up-regulated in human cancers; however, its role in liver CSCs is unknown. In this study, we explored...

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PMID: 27312708
DOI: 10.1002/hep.28690

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