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JNK Signaling in the Control of the Tumor-Initiating Capacity Associated with Cancer Stem Cells

22 Jan 2013

Abstract excerpt

Deregulation of c-Jun NH2-terminal kinase (JNK) signaling occurs frequently in a variety of human cancers, yet the exact role(s) of JNK deregulation in cancer cell biology remains to be fully elucidated. Our recent demonstration that the activity of JNK is required not only for self-renewal of glioma stem cells but also for their tumor initiation has, however, identified a new role for JNK in the control of the...

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PMID: 24349636
DOI: 10.1177/1947601912474892

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