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Article

SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A

7 Feb 2018

Abstract excerpt

Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in colorectal CSCs. Overexpression of SIRT6 in colorectal CSCs did not induce cell apoptosis. However,...

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Identifiers

PMID: 29552180
DOI: 10.3892/ol.2018.7989

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